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Cancer Clinical Trials

Site: Hematologic/Blood-Related

The most recent listing of current clinical trials for hematologic and blood-related cancers — including blood and marrow transplant/BMT, leukemia, non-Hodgkins lymphoma, Hodgkin's disease/lymphoma and multiple myeloma — appears below. Should you be interested in learning more about any of these clinical trials, please use our Contact Us form.
 

Site: Hematologic/Blood-Related
(Includes Blood and Marrow Transplant/BMT,
Leukemia, Non-Hodgkins Lymphoma,
Hodgkin's Disease/Lymphoma,
Lymphoma and Multiple Myeloma)

Protocol ID    Title

CTN-0303    A Single Arm, Multicenter Phase II Trial of Transplants of HLA-Matched, CD34 + Enriched, T Cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients with AML (Acute Myelogenous Leukemia) in First or Second Morphologic Complete Remission

Keywords: AML (Acute Myelogenous Leukemia) in first or second morphologic complete remission

Industry-AML    A Phase III Randomized, Double-Blind, Controlled Study Comparing Clofarabine and Cytarabine v. Cytarabine Alone in Adult Patients >= 60 Years Old with Acute Myelogenous Leukemia (AML) who have Relapsed or are Refractory after Receiving up to Two Prior Induction Regimens

Keywords: adult patients >= 60 years old with acute myelogenous leukemia (AML) who have relapsed or are refractory after receiving up to 2 prior induction regimens

In-House    Skin Biopsy and Use of Otherwise Discarded Cellular Material for Laboratory Validation

Keywords: skin biopsy

In-House    Skin Biopsy and Use of Normal Donor Apheresis Product in Laboratory Validation Studies

Keywords: skin biopsy

In-House    Kinetics of the Immune Response to Aspergillus Post Hematopoietic Progenitor Cell Transplantation

Keywords: post hematopoietic progenitor cell transplantation

Industry-280    A Phase III, Randomized, Double Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Prochymal (Ex-vivo Cultured Adult Human Mesenchymal Stem Cells) Infusion for the Treatment of Steroid- Refractory Acute GVHD

Keywords: steroid-refractory acute GVHD

In-House    Haploidentical Hematopoietic Stem Cell Transplantation (HCT) Using Highly Purified Hematopoietic Stem Cells

Keywords: haploidentical hematopoietic stem cell transplantation

In-House    Laboratory Studies of Iron Metabolism in Blood Cells from Patients with Hematochromatosis

Keywords: patients with hematochromatosis

In-House    Pre-Clinical Evaluation of Gallium Compounds in Chronic Lymphocytic Leukemia

Keywords: chronic lymphocytic leukemia (CLL)

FH 1591.00    Campath {Alemtuzumab} Dose Escalation, Low-Dose TBI and Fludarabine Followed by HLA Class I Mismatched Donor Stem Cell Transplantation for Patients with Hematologic Malignancies-A Multi-Center Trial

Keywords: hematologic malignancies

FH 1803.00    Donor Lymphocyte Infusion for the Treatment of Malignancy After Hematopoietic Cell Transplantation Using Nonmyeloablative Conditioning - A Multi-Center Trial

Keywords: after hematopoitic cell transplantation

FH 1813.00    A Multi-Center Phase III Study Comparing Nonmyeloablative Conditioning with TBI versus Fludarabine/TBI for HLA-Matched Related Hematopoietic Cell Transplantation for Treatment of Hematologic Malignancies

Keywords: HLA-Matched Related Hematopoietic Cell Transplantation for Treatment of Hematologic Malignancies

FH 1938.00    A Randomized Phase III Study to Determine the Most Promising Post grafting Immunosuppression for Prevention of Acute GVHD after Unrelated Donor G-CSF Mobilized Peripheral Blood Mononuclear Cell (G-PBMC) Transplantation Using Nonmyeloablative Conditioning for Patients with Hematologic Malignancies: A Multi-Center Trial

Keywords: after Unrelated Donor G-CSF Mobilized Peripheral Blood Mononuclear Cell (G-PBMC) Transplantation

FH 2054.00    Cyclophosphamide and Antithymocyte Globulin Conditioning Regimen for Marrow Transplantation from HLA-Matched Family Members for Severe Aplastic Anemia: Effect of Marrow Cell Dose on Chronic Graft-vs. Host Disease: A Multi-Center Trial

Keywords: Severe Aplastic Anemia

U of M    A Multicenter, Prospective Trial to Evaluate the Role of NK Cell Kir Epitope Mismatch on Mortality and Disease Relapse in T-Cell Depleted Hematopoietic Stem Cell Transplantation from HLA-C Mismatched, Unrelated Donors for Myeloid Malignancies

Keywords: hematopoietic stem cell transplants and myeloid malignancies

In-House:EBV Auto    A Study of Cellular Adoptive Immunotherapy as Treatment for EBV-LPD; Use of Autologous Epstein Barr Virus Specific Cytotoxic T-Lymphoctyes

Keywords: Treatment for Epstein Barr Virus

In-House: T-Cell    A Single Arm, Phase II Trial of Transplantation of HLA-Identical Sibling, CD34+ Enriched, Peripheral Blood Stem Cells Isolated by the Isolex System with a Fixed T-Cell Dose in the Treatment of Patients with Hematologic Malignancies

Keywords: Hematologic Malignancies

E2902    A Phase III Randomized Study of Farnesyl Transferase Inhibitor R115777 in Acute Myeloid Leukemia (AML) Patients in Second or Subsequent Remission or in Remission After Primary Induction Failure

Keywords: Acute Myeloid Leukemia (AML) Patients in Second or Subsequent Remission or in Remission After Primary Induction Failure

E5998    A Phase II Study of Initial Treatment with Methotrexate in Large Granular Lymphocytic (LGL) Leukemia

Keywords: Large Granular Lymphocytic (LGL) Leukemia

E4402    Randomized Phase III Trial Comparing Two Different Rituximab Dosing Regimens for Patients with Low Tumor Burden Indolent Non-Hodgkin's Lymphoma

Keywords: Patients with Low Tumor Burden Indolent Non-Hodgkin's Lymphoma

C100104    A Phase III Randomized, Double-Blind Study of Maintenance Therapy with CC-5013 (NSC #703813, IND #70116) or Placebo Following Autologous Stem Cell Transplantation for Multiple Myeloma

Keywords: Multiple Myeloma

Industry-NHL    A Randomized, Open-Label, Multicenter Study of VELCADE with Rituximab or Rituximab Alone in Subjects with Relapsed or Refractory, Rituximab Naïve or Sensitive Follicular B-Cell Non-Hodgkin's Lymphoma

Keywords: Relapsed or Refractory, Rituximab Naïve or Sensitive Follicular B-Cell Non-Hodgkin's Lymphoma

Industry-transplant    Compassionate Use Protocol for the use of AMD3100 to Mobilize Peripheral Blood Stem Cells for the Collection and Transplantation

Keywords: transplantation

In-House: Pre-Clinical
Vaccine for MM
   Pre-Clinical Studies on Vaccine Derived From Patient-Derived Myeloma Cells

Keywords: Multiple Myeloma

In-House    A Randomized Phase II Study of Zoledronic Acid (Zometa ®) in the Prevention of Osteoporosis in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Keywords: allogenic hematopoietic stem cell transplant

In-House: Technetium    Development of 99m Technetium Scanning as a Quantitative in Vivo Assay to Predict Chemotherapy Drug Resistance and Clinical Outcome in Lymphoma Patients

Keywords: Lymphoma

AVF4064g    A Randomized, Blinded, Placebo Controlled, Multicenter, Phase II Study of Bevcizumab in Combination with Bortezomib Compared with Bortezomib in Patients with Relapsed or Refractory Multiple Myeloma

Keywords: Relapsed or Refractory Multiple Myeloma

E3402    A Phase II Trial of R-CHOP Followed by Zevalin Radioimmunotherapy for Patients with Previously Untreated Stages I and II CD20+ Diffuse Large Cell Non-Hodgkin's Lymphoma

Keywords: diffuse large cell non-Hodgkin’s lymphoma

E1405    A Phase II study of VcR-CVAD with Rituximab Maintenance for Untreated Mantle Cell Lymphoma

Keywords: Untreated Mantle Cell Lymphoma

E3404    Response-Adapted Therapy for Aggressive Non-Hodgkin's Lymphoma based on Early (18F) FDG-PET Scanning

Keywords: Non-Hodgkin's Lymphoma

CTN-0401    Phase III Rituxan/ BEAM vs. Bexxar/ BEAM with Autologous Hematopoietic Stem Cell Transplantation (ASCT) for Persistent or Relapsed Chemotherapy Sensitive Diffuse Large B-Cell Non-Hodgkin's Lymphoma

Keywords: Persistent or Relapsed Chemotherapy Sensitive Diffuse Large B-Cell Non-Hodgkin's Lymphoma

Millennium C05008    Phase I/II Study of VELCADE (Bortezomib), Dexamethasone, and Revlimid (VDCR) in Subjects with Previously Untreated Multiple Myeloma

Keywords: Previously Untreated Multiple Myeloma

S0106    A Phase III Study of the Addition of Gemtuzumab Ozogamicin (Mylotarg) During Induction Therapy Versus Standard Induction with Daunomycin and Cytosine Arabinoside Followed by Consolidation and Subsequent Randomization to Post-Consolidation Therapy with Gemtuzumab Ozogamicin (Mylotarg) or no Additional Therapy for Patients Under Age 61 with Previously Untreated DeNovo Acute Myeloid Luekemia

Keywords: Patients Under Age 61 with Previously Untreated DeNovo Acute Myeloid Luekemia

S9007    Cytogenetic Studies in Leukemia Patients

Keywords: Leukemia

S9910    Leukemia Centralized Reference Laboratories and Tissue Repositories

Keywords: Leukemia

S0325    A Phase IIB Study of Molecular Responses to Imatinib, at Standard or Increased Doses, or Dasatinib (BMS-354825) (NSC-732517) for Previously Untreated Patients with Chronic Myelogenous Leukemia (CML) in Chronic Phase

Keywords: Previously Untreated Patients with Chronic Myelogenous Leukemia (CML) in Chronic Phase

SCOT    A Randomized , Open label, Phase II/III Multicenter Study of High-Dose Immunosuppressive Therapy Using Total Body Irradiation, Cyclophosphamide, ATGAM, and Autologous Transplantation with Auto-CD34+HPC Versus Intravenous Pulse Cyclophosphamide for the Treatment of Severe Systemic Sclerosis

Keywords: Severe Systemic Sclerosis

 

 

Last Review Date: May 30, 2008

Online Editor(s): Rich Petre

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