Heart and Vascular Clinical Trials

The Froedtert & the Medical College of Wisconsin Heart and Vascular Center combines specialty expertise, state-of-the-science technology and consistent research leadership to provide comprehensive services for all heart and vascular disorders. Our physicians and staff are dedicated to providing their patients with the most up-to-date heart and vascular treatment options. At any given time we offer many clinical trials for qualifying patients. 

The trials listed below are updated quarterly. It is possible since the last update that a trial on the list has closed. It is also possible that new trials have opened that are not listed.

Final eligibility for clinical trial is determined by the health professionals conducting the trial.

Category: Advanced Heart Failure


Title
Interagency Registry of Mechanical Assisted Circulatory Support

Status
Enrolling subjects

Keywords
MCS, VAD, CMS, Advanced Heart Failure, Heart Transplant; NCT00119834

Title
SynCardia Freedom™ Driver System Study

Status
Enrolling subjects

Keywords
MCS, TAH-t, CMS, bi-ventricular failure, Advanced Heart Failure, Heart Transplant; NCT00733447

Title
Exploring Biomarkers for the Diagnosis of Heart Failure with Preserved Ejection Fraction

Status
Enrolling subjects

Keywords
Diastolic dysfunction, biomarkers, HFpEF

Category: Cardiology Imaging


Title
MagnaSafe Registry: Determining the Risks of Magnetic Resonance Imaging in the Presence of Pacemakers and Implantable Cardioverter Defibrillators

Status
Enrolling subjects

Keywords
Pacemaker, AICD, MRI, diagnostic imaging, NIH; NCT00907361

Category: Diabetic Medication and Its Effects on Blood Vessel Function


Title
A randomized, crossover design study of acute and chronic effects of sitagliptin on endothelial function in humans with type 2 diabetes on background metformin therapy

Status
Enrolling subjects

Keywords

Diabetes, endothelial dysfunction, cardiovascular diseases, vascular diseases; NCT01859793


Category: Electrophysiology and Arrhythmia Services


Title
Validation of the Durability of the Adenosine Effect in Verification of Pulmonary Vein Isolation

Status
Enrolling subjects

Keywords
Atrial Fibrillation, Ablation, Adenosine; NCT01590875

Category: Peripheral Vascular Disease


Title
A multicenter, randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy, safety, and tolerability of ixmyelocel-T in subjects with critical limb ischemia and no options for revascularization [PROTOCOL NUMBER: 55-1009-1].  REVIVE-CLI.

Status
Enrolling subjects

Keywords
PAD, CLI, PVD, wound healing; NCT01483898

Category: PFO and Embolic CVA


Title
403-03 IDE# G990318: Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Establish Current Standard Care Treatment (RESPECT)

Status
Follow-up only

Keywords
PFO (patent foramen ovale), embolic stroke, cardiac embolism, cryptogenic stroke, NCT00465270

Title
PFO ACCESS Registry:  Patent Foramen Ovale Closure with the Amplatzer PFO Occluder in Patients with recurrent Cryptogenic Stroke due to Presumed Paradoxical Embolism through a Patent Foramen Ovale who have Failed Conventional Drug Therapy.

Status
Enrolling Subjects

Keywords
PFO (patent foramen ovale), embolic stroke, cardiac embolism, cryptogenic stroke

Title
GORE HELEX™ Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke or Imaging- Confirmed TIA in Patients with Patent Foramen Ovale (PFO).Study Protocol Number: HLX 06-03.  The GORE REDUCE Study

Status
Enrolling Subjects

Keywords
PFO (patent foramen ovale), embolic stroke, cardiac embolism, cryptogenic stroke, NCT00738894


Category: PFO and Migraine


Title
Prospective Randomized investigation to Evaluate incidence of headache reduction in subjects with Migraine and PFO Using the AMPLATZER PFO Occluder compared to medical Management.  IDE#: G050054

Status
Enrolling subjects

Keywords
PFO (patent foramen ovale), migraine headaches; NCT00355056

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