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MRI-ENHANCE MRI-Guided Adaptive Radiation Therapy for Organ Preservation in Rectal Cancer

Protocol No
IIT-HALL-MRI-ENHANCE
Principal Investigator
William Hall
Phase
I/II
Summary
The purpose of this study is to test an experimental treatment for your rectal adenocarcinoma. This study will use a new way of administering radiation therapy for rectal adenocarcinoma called Magnetic Resonance-guided Adaptive Radiation Therapy (MRgART) in addition to the standard radiation therapy for your type of cancer. MRgART uses MRI scans taken throughout treatment to track how the cancer changes. The study doctors will then adapt their treatment plan as needed. This makes it possible to increase the dose of radiation given to specific areas that need it while reducing the dose of radiation given to specific areas where the tumor is getting smaller. The addition of the MRgART treatment will give a higher dose of radiation compared to the standard radiation therapy. But because it will be more targeted, the study doctors hope this treatment will be more beneficial to treat the cancer while causing limited additional side effects. Subjects in this study may also receive any neoadjuvant chemotherapy in combination with radiation therapy as prescribed by the study doctors.
Description
This project is being done to to test an experimental treatment for your rectal adenocarcinoma called Magnetic Resonanceguided Adaptive Radiation Therapy in addition to the standard radiation therapy for your type of cancer.
Participating Institutions
Froedtert Hospital
Status
OPEN TO ACCRUAL