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A Multicenter Phase II Trial Of Paclitaxel With And Without Nivolumab In Taxane Naïve, And Nivolumab And Cabozantinib In Taxane Pretreated Subjects With Angiosarcoma

Protocol No
ALLIANCE-A091902
Principal Investigator
John Charlson
Phase
II
Summary
The purpose of this study is to: 1. Compare treatment with chemotherapy (paclitaxel) alone to using a combination of nivolumab plus chemotherapy (paclitaxel) treatment in patients with angiosarcoma who have not been treated with paclitaxel chemotherapy alone. 2. Evaluate the effect of nivolumab in combination with cabozantinib on angiosarcoma (cancer) in patients who have either received paclitaxel or similar chemotherapy previously, or whose cancer has grown previously while getting paclitaxel chemotherapy on this study.
Description
Testing the Addition of Nivolumab to chemotherapy in Treatment of Soft Tissue Sarcoma
Participating Institutions
Froedtert Hospital
Status
OPEN TO ACCRUAL
Sub Category