Optimizing NeuroCOgnition with Whole Brain Radiation Therapy (WBRT) using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique (ONCO-RT) - A Phase II Trial of Upfront Pulsed Reduced Dose Rate Whole Brain Radiation Therapy for Brain Metastases

Protocol No
IIT-SAEED-ONCO-RT
Principal Investigator
Lindsay Puckett
Phase
II
Summary
The standard approach to treat solid tumor cancer that has metastasized to the brain is with whole brain radiation therapy. However, a common side effect of this treatment is worsening neurocognitive function including memory loss, reduced brain function, and motor function decline. This project is being done to test a new technique called pulsed reduced dose-rate (PRDR) whole brain radiation therapy in combination with the drug Memantine to reduce the neurocognitive effects of treating brain metastases. Researchers believe that this treatment regimen will have better outcomes after treatment of brain metastases.
Description
This project is being done to test a new technique called pulsed reduced dose-rate
(PRDR) whole brain radiation therapy in combination with the drug Memantine to reduce the
neurocognitive effects of treating brain metastases.
Participating Institutions
Drexel Town Center
Froedtert Menomonee Falls Hospital
Froedtert Hospital
Status
OPEN TO ACCRUAL