The purpose of this study is to find out about the safety and tolerability of the study drug, KPG-818 for the treatment of hematological malignancies. This study will also help to identify a recommended dose to study further in subjects with these selected hematological malignancies.
Open-label, multiple-ascending dose study to evaluate the safety, PK, and preliminary clinical activity of KPG-818 as a single agent in adult subjects with selected hematological malignancies, except for multiple myeloma indication. KPG-818 will be used in combination with dexamethasone for dose escalation and dose expansion. The study will consist of 2 parts: Part 1 dose escalation and Part 2 dose expansion.
OPEN TO ACCRUAL