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A Phase Ib/II, Open-Label, Multicenter, Randomized, Umbrella Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer)

Protocol No
HOFFMANN-LAROCHE-YO39609
Principal Investigator
Ben George
Phase
I/II
Summary
This study will evaluate the efficacy, safety, and pharmacokinetics of immunotherapy-based treatment combinations in patients with gastric or gastroesophageal junction cancer and esophageal cancer.
Description
To evaluate the efficacy of immunotherapy-based treatment combinations in all arms and to characterize the PK profile of drugs that are administered as part of an immunotherapy-based treatment combinations. Evaluate the immune response to drugs and the potential effects of anti-drug antibodies.
Participating Institutions
Froedtert Hospital
Status
OPEN TO ACCRUAL
Sub Category
Gastrointestinal Cancers
ClinicalTrials.gov
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