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Phase II Randomized Trial Of Neo-Adjuvant Chemotherapy Followed By Surgery And Post-Operative Radiation Versus Surgery And Post-Operative Radiation For Organ Preservation Of T3 And T4a Nasal And Paranasal Sinus Squamous Cell Carcinoma (NPNSCC)

Protocol No
Principal Investigator
Stuart Wong
The purpose of this research study is to compare the effects of chemotherapy with docetaxel and cisplatin or carboplatin on avoiding the need to remove the eye and/or skull bone and on the chance of surviving the cancer. In this research study, you will get either chemotherapy (with Docetaxel and Cisplatin or Carboplatin) followed by surgery and radiation therapy, or the standard of care of surgery followed by radiation therapy. Another purpose of this research study is to determine the accuracy of imaging in predicting eye and skull base preservation as well as predicting overall survival after 2 years. There will be about 134 people taking part in this study.
Testing the Addition of Chemotherapy to the Treatment of Cancer of the Sinonasal Area
Participating Institutions
Froedtert Hospital
Sub Category