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A Phase II Study of MRI-Based Pre-Operative Accelerated Partial Breast Irradiation

Protocol No
Principal Investigator
Adam Currey
In this study we want to find out more about pre-operative accelerated partial breast irradiation in people with early stage breast cancer. Delivering radiation prior to surgery might have the potential to reduce some of the long term effects of radiation. It may also increase in surgical complications. The main purpose of this study is find out whether the new radiation technique is safe and doesn t cause an excessive number of surgical complications. We also want to see if using MRI to help guide radiation and delivering the radiation in the pre-operative setting reduces the long term side effects of accelerated partial breast irradiation. Because most patients receive radiation after their tumor is removed from their breast, it is difficulty to study the effects of the radiation on the tumor. In this study, we also plan to investigate how the appearance of your tumor on an MRI scan changes after radiation treatments and how the genetic make-up of that tumor changes after radiation treatment. Everyone in this study will receive pre-operative accelerated partial breast irradiation, which is still experimental and is not a standard treatment at this time. We are testing this novel radiation approach to see what effect it has on people with breast cancer. We don t know if this study will help you. Your condition may get better but it could stay the same or even get worse. We hope the information from this study will help us develop a better treatment for breast cancer in the future.
MRI-Based Preoperative Accelerated Partial Breast Irradiation
Participating Institutions
Froedtert Hospital
Froedtert West Bend Hospital
Froedtert Menomonee Falls Hospital
Sub Category