Randomized Phase II/III Trial of Radiation with High-Dose Cisplatin (100 MG/M2) Every Three Weeks Versus Radiation with Low-Dose Weekly Cisplatin (40 MG/M2) for Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)

Protocol No
NRG-HN009
Principal Investigator
Aditya Shreenivas
Phase
II/III
Summary
This study is being done to answer the following questions: 1. Does low-dose cisplatin given weekly with radiation have fewer side effects than high-dose cisplatin given every 3 weeks with radiation? 2. Can low-dose cisplatin given weekly with radiation extend your life by at least the same amount of time as high-dose cisplatin given every 3 weeks with radiation?
Description
Comparing high-dose cisplatin every three weeks to low-dose cisplatin weekly when combined with radiation for patients with advanced head and neck cancer

Participating Institutions
Drexel Town Center
Froedtert Hospital
Froedtert West Bend Hospital
Froedtert Menomonee Falls Hospital
Status
OPEN TO ACCRUAL
Sub Category
Head and Neck Cancers
ClinicalTrials.gov
go to website