Optimizing Neurocognition with Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique (ONCO-RT) - A Phase II Trial of Upfront Pulsed Reduced Dose Rate Whole Brain Radiation Therapy for Brain Metastases

The standard approach to treat solid tumor cancer that has metastasized to the brain is with
whole brain radiation therapy. However, a common side effect of this treatment is worsening
neurocognitive function including memory loss, reduced brain function, and motor function
decline. This project is being done to test a new technique called pulsed reduced dose-rate
(PRDR) whole brain radiation therapy in combination with the drug Memantine to reduce the
neurocognitive effects of treating brain metastases. Researchers believe that this treatment
regimen will have better outcomes after treatment of brain metastases.