A Phase 2 , Open-Label, Multicenter, Randomized Study Evaluating Neoadjuvant Therapy Targeting the Adenosine Immunosuppressive Pathway in Combination with Immune Checkpoint Blockade and Radiation Therapy in Patients with Advanced PANCreatic Ductal Adenocarcinoma Who Are Candidates For Surgical Resection

Protocol No
COLUMBIA-AAAU4206-AIRPANC
Staff Member
Ben George
Phase
II
Summary

This project is being done to find out if study treatment with zimberelimab and stereotactic body radiation therapy [SBRT] alone or in combination with quemliclustat, with or without etrumadenant given before surgery is safe and if it can further increase the immune response against the tumor.
Objective
Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma (AIRPanc)
Study Sites
Froedtert Hospital
Status
OPEN TO ACCRUAL
Categories
Cancer, Pancreas/Liver, Gastrointestinal Cancers
ClinicalTrials.gov
https://www.clinicaltrials.gov/study/NCT06048484