A Phase III Randomized Trial of Steroids + Tyrosine Kinase Inhibitor (TKI) Induction with Chemotherapy or Blinatumomab for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia (ALL) in Adults

Protocol No

ECOG-EA9181-ALL

Staff Member

Ehab Atallah

Phase

III

Summary

This study is being done to determine what effects (good or bad) using the combination of potent TKI, steroids and blinatumomab versus treatment with steroids, TKI and chemotherapy. This investigational therapy will be added to what has traditionally been used to treat this specific sub-type of ALL. Studies are being done in ALL and other blood cancers with blinatumomab.

Objective

Steroids plus TKI with Blinatumomab or Chemo for Newly Diagnosed BCR-ABL Positive ALL in Adults

Study Sites

Froedtert Hospital

Status

OPEN TO ACCRUAL