Phase III Trial of Salvage Stereotactic Radiosurgery (SRS) or SRS + Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for First or Second Distant Brain Relapse After Upfront SRS with Brain Metastasis Velocity >/= 4 Brain Metastases/Year

Protocol No

This study is being done to answer the following question: Can we extend your life by adding a type of radiation therapy called whole-brain radiation therapy that avoids the hippocampus (HA-WBRT) to preserve memory plus the medication memantine that is FDA approved to treat dementia to the usual treatment? We are doing this study because we want to find out if adding HA-WBRT and memantine is better or worse than the usual approach for your brain cancer. The usual approach is defined as care most people get for cancer that has spread to the brain and returned in other areas of the brain after receiving Stereotactic Radiosurgery (SRS).

Testing the Addition of Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in People With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery
Participating Institutions
Drexel Town Center
Froedtert Hospital