A Phase III Trial of Stereotactic Radiosurgery Compared with Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

This study is being done to answer the following question: Can we reduce your symptoms and lower the chance of the cancer growing or getting worse by using stereotactic radiosurgery, compared to the usual radiotherapy? Stereotactic radiosurgery or SRS is a commonly used treatment for brain tumors. It is a one-day (or in some cases two day), out-patient procedure during which a high dose of radiation is delivered to small spots in the brain while excluding the surrounding normal brain.

We are doing this study because we want to find out if this approach is better or worse than the usual approach for your type of cancer. The usual approach is defined as care most people get for cancer that has spread to the brain.