Cardiomyopathy is any disease of the heart muscle in which the heart loses its ability to pump blood effectively. The condition affects about 50,000 American adults and children. There may be multiple causes of cardiomyopathy and it may be associated with diseases involving other organs, as well as the heart.

Cardiomyopathy conditions tend to be progressive and sometimes worsen fairly quickly. Dilated cardiomyopathy is a leading cause for a heart transplant. Patients with cardiomyopathy are more likely to develop ventricular arrhythmias, which increases their risk of cardiac arrest. Certain diagnostic tests can be performed to help predict the patient's risk of cardiac arrest and guide physicians in recommending proper treatment.

What Causes Cardiomyopathy?

Viral infections that affect the heart are a major cause of cardiomyopathy. In some instances, cardiomyopathy is a result of another disease or its treatment, such as complex congenital heart disease (present at birth), nutritional deficiencies, irregular heart rhythms (arrhythmia) or certain types of chemotherapy for cancer. Sometimes, cardiomyopathy can be linked to a genetic abnormality. Other times, the cause is unknown.

Types of Cardiomyopathy

Hypertrophic Cardiomyopathy (HCM)

Hypertrophic cardiomyopathy occurs when the muscle mass of the left ventricle of the heart is thicker than normal, or the wall between the two ventricles (septum) becomes enlarged and obstructs the blood flow from the left ventricle. Because it prevents the heart from properly relaxing between beats, it fills with less blood, which limits the amount of blood pumped by the heart with each beat. A heart murmur may be heard, which is related to the obstruction below the aortic valve (valve between the left ventricle and the aorta).

Hypertrophic cardiomyopathy is a rare disease and in most cases it is inherited. It can affect men and women of all ages, and symptoms can appear in childhood or adulthood. Symptoms include shortness of breath on exertion, dizziness, fainting and angina pectoris. Some patients experience cardiac arrhythmias, which may lead to sudden death. Learn more about specialized Froedtert & the Medical College of Wisconsin's highly specialized hypertrophic cardiomyopathy program.

Dilated Cardiomyopathy

Dilated cardiomyopathy is the most frequent form of nonischemic cardiomyopathy (those not related to coronary artery disease). The cavity of the heart is enlarged and stretched (cardiac dilation) causing the heart to become weak and not pump normally. The condition occurs most often in middle-aged people and more often in men than women, but has been diagnosed in children. Most patients develop congestive heart failure.

Dilated cardiomyopathy can be caused by alcohol abuse and dietary deficiencies. It occasionally occurs as a complication of pregnancy and childbirth. Other suggested causes are: various infections (which lead to an inflammation of the heart muscle, called myocarditis), toxins, heredity and medication side effects.

Restrictive Cardiomyopathy

Restrictive cardiomyopathy, the least common type of cardiomyopathy in the US, occurs when the myocardium of the ventricles becomes excessively rigid, and the filling of the ventricles with blood between heart beats is impaired. The condition usually results from another disease, which occurs elsewhere in the body. Symptoms may include fatigue, swelling of the extremities, and difficulty breathing on exertion.

Genetic Testing for Inherited Cardiomyopathy

Cardiac MRI and other tests can be conducted by cardiac geneticists to determine if a patient has an inherited cardiomyopathy condition. Testing can confirm a diagnosis in someone showing signs of the condition. It can also identify family members at risk of developing the condition later in life so they can be screened regularly and treated as soon as heart changes begin to appear. These conditions are often associated with an electrical problem in the heart, or arrhythmia (irregular heartbeats).

In addition to hypertrophic cardiomyopathy (HCM), other genetic cardiomyopathies include:

  • Long Q-T syndrome, a hereditary disorder of the heart’s electrical rhythm that involves repeated fainting and a high risk of cardiac arrest.
  • Arrhythmogenic right ventricular dysplasia (ARVD), a genetic, progressive heart condition in which the heart’s right ventricle muscle is replaced by fat and fibrosis, causing irregular heart rhythms.
  • Brugada Syndrome, an inherited, potentially life-threatening heart rhythm disorder diagnosed when a specific abnormal heartbeat is detected by an electrocardiogram.

Treatments for cardiomyopathy often include medications, implantable defibrillators or bi-ventricular devices.

Our Cardiovascular Program continues to receive recognition as one of the top programs nationally. We are honored to provide high-quality, effective care for even the most high-risk patients.

  • The Froedtert & MCW health network has built a reputation for clinical excellence and our research draws patients from around the world. Our Heart & Vascular program recognitions include:

    • Premier recognized Froedtert Hospital in 2025 as one of the nation’s 50 Top Cardiovascular Hospitals® according to its independent quality analysis based on a balanced scorecard. The hospitals recognized in the top 50 operated at lower cost and had better outcomes, recording significantly higher inpatient survival rates, fewer patients with complications, lower readmission rates and up to nearly $7,000 less in total costs per patient case. Froedtert Hospital was ranked in the category of top teaching hospitals with a cardiovascular residency program. No other hospital in Wisconsin was recognized with this national distinction.
    • The International Cardio-Oncology Society (ICOS) recognizes our Cardio-Oncology Program as a gold level Cardio-Oncology Center of Excellence in 2025. ICOS certification is awarded to institutions and practices that demonstrate superior expertise in the care of patients who have heart disease, are at high risk or experience heart complications with cancer treatment. The ICOS awards bronze, silver and gold certification. Of the two ICOS-certified programs in Wisconsin, we are the only one that meets the stringent requirements needed to be recognized as a gold level Cardio-Oncology Center of Excellence.
    • Healthgrades recognized Froedtert Hospital in its 2024 Specialty Excellence Awards, including one of America’s 50 Best Hospitals for Cardiac Surgery, one of America’s 100 Best Hospitals for Cardiac Care and one of America’s 100 Best Hospitals for Coronary Intervention, as well as other specialty achievements in various areas.
    • Becker’s Hospital Review recognized Froedtert Hospital within its 2024 list of 100 Hospitals and Health Systems with Great Heart Programs. Hospitals featured on this list are renowned for delivering superior heart and vascular care that results in high-quality outcomes. As part of a health network that includes eastern Wisconsin’s only academic medical center, our heart and vascular specialists treat a high volume of patients with a wide variety of heart diseases.
    • The Society for Vascular Surgery's Vascular Quality Initiative (SVS VQI) recognized Froedert Hospital as a Carotid Care Quality Champion by the SVS VQI‘s clinical registry recognition program in 2024. The VQI recognizes select centers across the country as Carotid Care Quality Champions for their dedication to improving the safety and effectiveness of vascular care through participation and engagement in VQI’s carotid artery stenting and/or carotid endarterectomy registries.
    • The American Heart Association recognized Froedtert Hospital with the following awards that show our commitment to improving care by adhering to the latest treatment guidelines and streamlining processes to ensure timely and proper care for heart attacks.
      • Get With the Guidelines® Heart Failure Gold Plus Award
      • Get With the Guidelines® — Coronary Artery Disease STEMI Receiving Gold Plus with Target: Type 2 Diabetes
      • Get With the Guidelines® — Coronary Artery Disease NSTEMI Gold with Target: Type 2 Diabetes
      • Get With the Guidelines® AFib Gold Award
      • In addition, the hospital was recognized on the AHA’s Target: Heart Failure(SM) Honor Roll and received the AHA’s Target: Type 2 Diabetes Honor Roll™ award.