Randomized Phase II/III Trial of Adjuvant Radiation Therapy with Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck

First part of the study
The purpose of the this part of this study is to find out what effects, good and/or bad,
one of the following treatments has on you and your cancer. In this part of the study,
you will receive one of the following treatments:
1. Standard treatment: radiation therapy and cisplatin
2. Experimental treatment: radiation therapy and docetaxel
3. Experimental treatment: radiation therapy, docetaxel, and cetuximab

Second part of the study
This part of the study will proceed only if certain results are achieved in the first
part of the study.
The purpose of this part of this study is to compare the effects, good and/or bad, of the
standard treatment (radiation therapy and cisplatin) with one of the experimental
treatments chosen from the first part of the study (either radiation therapy and docetaxel
or radiation therapy, cetuximab, and docetaxel) to find out which is better. In this part of
the study, you will get either the standard treatment or the experimental treatment.