If you have questions, please call us for more information about clinical trials or use our online form.

Learn more about clinical trials basics and early-phase clinical trials, as well as some of the unique features our research program, including our Translational Research Unit. Froedtert & MCW health network is also part of the National Institutes of Health All of Us Research Program.  

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High Dose Re-Irradiation Utilizing Advanced Deformable Image Registration (DIR) and Individualized Organ At Risk (OAR) Dose Calculations with Organ Specific Toxicity Analysis (Re-DIRICT)

A Phase II study of Re-Irradiation Utilizing DIR and OAR Dose Calculations with Organ Specific Toxicity Analysis
Protocol No
IIT-GORE-REDIRICT
Categories
Cancer, Colorectal, Thoracic Cancers, Sarcoma, Skin Cancers, Prostate and Urologic Cancers, Head and Neck Cancers, Gynecologic Cancers, Gastrointestinal Cancers, Endocrine Cancers, Breast Cancers, Brain and Spine Cancers, Other Respiratory, Lung, Esophagus, Other Skin, Melanoma, Skin, Other Urologic, Bladder, Prostate, Kidney, Lip, Oral Cavity and Pharynx, Larynx, Other Gynecologic, Uterine, Ovary, Cervix, Other Gastrointestinal, Stomach, Pancreas/Liver, Esophagus

A Phase I, Open-Label, Multicenter, Dose Escalation and Cohort Expansion Study of SPYK04 as Monotherapy in Patients with Locally Advanced or Metastatic Solid Tumors

A Phase 1 Study of Spyk04 as Monotherapy in Patients with Solid Tumors
Protocol No
CHUGAI-SPK101JG
Categories
Cancer, Ovary, Early Phase/Multiple Disease Site Cancers, Thoracic Cancers, Sarcoma, Skin Cancers, Prostate and Urologic Cancers, Head and Neck Cancers, Gastrointestinal Cancers, Breast Cancers, Lung, Esophagus, Other Skin, Melanoma, Skin, Other Urologic, Bladder, Prostate, Kidney, Lip, Oral Cavity and Pharynx, Larynx, Other Gynecologic, Uterine, Cervix, Other Gastrointestinal, Stomach, Pancreas/Liver, Esophagus, Colorectal, Gynecologic Cancers

Tumor-Agnostic Precision Immunooncology and Somatic Targeting Rational for You (TAPISTRY) Phase II Platform Trial

This study will evaluate the efficacy and safety of multiple therapies that are selected
using somatic alterations and potential predictive biomarkers identified via NGS assays
in patients with solid tumors.
Protocol No
HOFFMANN-BO41932-TAPISTRY
Categories
Cancer, Gynecologic Cancers, Early Phase/Multiple Disease Site Cancers, Thoracic Cancers, Prostate and Urologic Cancers, Gastrointestinal Cancers, Esophagus, Bladder, Prostate, Kidney, Lip, Oral Cavity and Pharynx, Uterine, Ovary, Cervix, Stomach, Pancreas/Liver, Esophagus, Head and Neck Cancers

A Phase 1, Open-Label, Multicenter Study to Assess Safety, Tolerability, PK, and Efficacy of MK-1084 as Monotherapy and in Combination with Pembrolizumab in Subjects with KRAS G12C Mutant Advanced Solid Tumors

This project is being done to test the safety and tolerability of MK-1084 alone in combination with pembrolizumab in patients with solid tumor cancers that have a mutated KRAS gene.
Protocol No
MERCK-MK1084-001
Categories
Cancer, Colorectal, Early Phase/Multiple Disease Site Cancers, Thoracic Cancers, Sarcoma, Skin Cancers, Prostate and Urologic Cancers, Head and Neck Cancers, Gynecologic Cancers, Gastrointestinal Cancers, Eye/Orbital Cancers, Endocrine Cancers, Breast Cancers, Lung, Esophagus, Other Skin, Melanoma, Skin, Other Urologic, Bladder, Prostate, Kidney, Lip, Oral Cavity and Pharynx, Larynx, Other Gynecologic, Uterine, Ovary, Cervix, Other Gastrointestinal, Stomach, Pancreas/Liver, Esophagus

A Randomized Phase III Trial of Pre-Operative Compared to Post-Operative Stereotactic Radiosurgery in Patients with Resectable Brain Metastases

Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases
Protocol No
NRG-BN012
Categories
Cancer, Colorectal, Early Phase/Multiple Disease Site Cancers, Thoracic Cancers, Sarcoma, Skin Cancers, Prostate and Urologic Cancers, Head and Neck Cancers, Gynecologic Cancers, Gastrointestinal Cancers, Endocrine Cancers, Breast Cancers, Lung, Esophagus, Melanoma, Skin, Bladder, Prostate, Kidney, Lip, Oral Cavity and Pharynx, Larynx, Uterine, Ovary, Cervix, Stomach, Pancreas/Liver, Esophagus

A Phase 3, Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial of Selinexor in Maintenance Therapy After Systemic Therapy for Patients with P53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

Selinexor is a medicine that is FDA approved for other cancer but not for endometrial cancer (EC). Selinexor was investigated in a prior study and demonstrated promising activity in a subgroup of patients with TP53 wild-type EC. To date there are no approved treatment options in the maintenance setting for patients with advanced or recurrent EC following response to chemotherapy. In this research study, we will investigate the safety and effectiveness of selinexor for maintenance in patients with TP53 wild-type endometrial cancer.
Protocol No
GOG-3083-XPORT-EC-042SELINEXOR
Categories
Cancer, Uterine, Gynecologic Cancers